Author(s): Cramer DW, Barbieri RL, Muto MG, Kelly A, Brucks JP, et al.
Background: Although there is a basis for linking pituitary or ovarian hormones with experimentally induced ovarian cancer, establishing their role in women is complicated because the usual case-control methods cannot be applied. In this study, hormonal levels in women with a family history of ovarian cancer (FOC) and who are at higher risk for the disease are compared with women without such a history.
Methods: The authors studied 106 unrelated women (FOC patients) with at least one primary or two second-degree relatives with ovarian cancer compared with 116 age- and residence-matched controls without a family history of ovarian cancer (FOC control subjects). All women were premenopausal, between the ages of 25 and 49 years, not currently using oral contraceptives, and had blood drawn during the early follicular phase for gonadotropins, estradiol (E2), and CA-125.
Results: Women with a family history of ovarian cancer and control subjects did not differ significantly in follicle stimulating hormone (FSH) levels, E2, or CA-125. Patients with a family history of ovarian cancer had significantly lower luteinizing hormone (LH) levels compared with control subjects and produced more E2 and FSH relative to their level of LH. The ratios of LH to E2 and LH to FSH were correlated with the enzymatic activity of galactose-1-phosphate uridyl transferase, which was shown previously to differ between FOC patients and control subjects.
Conclusion: Lower LH and higher E2 are reported in women with breast, endometrial, and ovarian cancer (before surgery). The authors speculate that these observations reflect greater LH binding and estradiol production in ovaries at risk for these cancers--the ovarian cortical hyperplasia postulated in older gynecologic literature as the precursor to estrogen dependent neoplasia.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/8055454
Author(s): Kurman RJ, Norris HJ
Author(s): Lacey JV Jr, Ioffe OB, Ronnett BM, Rush BB, Richesson DA, et al.
Author(s): Reed SD, Newton KM, Clinton WL, Epplein M, Garcia R, et al.
Author(s): Kurman RJ, Shih IeM
Author(s): Lacey JV Jr, Sherman ME, Rush BB, Ronnett BM, Ioffe OB, et al.
Author(s): Ferenczy A
Author(s): Stein CJ, Colditz GA
Author(s): Reed SD, Newton KM, Garcia RL, Allison KH, Voigt LF, et al.
Author(s): Ricci E, Moroni S, Parazzini F, Surace M, Benzi G, et al.
Author(s): Bobrowska K, Kamiński P, Cyganek A, Pietrzak B, Jabiry-Zieniewicz Z, et al.
Author(s): Heller DS, Mosquera C, Goldsmith LT, Cracchiolo B
Author(s): Gregoriou O, Konidaris S, Vrachnis N, Bakalianou K, Salakos N, et al.
Author(s): DerSimonian R, Kacker R
Author(s): Higgins JP, Thompson SG, Deeks JJ, Altman DG
Author(s): Higgins JP, Thompson SG
Author(s): Egger M, Davey Smith G, Schneider M, Minder C
Author(s): Epplein M, Reed SD, Voigt LF, Newton KM, Holt VL, et al.
Author(s): Cheung AP
Author(s): Viola AS, Gouveia D, Andrade L, Aldrighi JM, Viola CF, et al.
Author(s): Kreiger N, Marrett LD, Clarke EA, Hilditch S, Woolever CA
Author(s): Weir HK, Sloan M, Kreiger N
Author(s): Epplein M, Reed SD, Voigt LF, Newton KM, Holt VL, et al.
Author(s): Nagamani M, Urban RJ
Author(s): Al-Jarrah M, Matalka I, Aseri HA, Mohtaseb A, Smirnova IV, et al.
Author(s): Guh DP, Zhang W, Bansback N, Amarsi Z, Birmingham CL, et al.
Author(s): Tankó LB, Christiansen C
Author(s): Midgette AS, Baron JA
Author(s): Willett W, Stampfer MJ, Bain C, Lipnick R, Speizer FE, et al.
Author(s): Gandini S, Botteri E, Iodice S, Boniol M, Lowenfels AB, et al.
Author(s): Botteri E, Iodice S, Bagnardi V, Raimondi S, Lowenfels AB, et al.
Author(s): Thune I, Furberg AS
Author(s): Schonfeld SJ, Hartge P, Pfeiffer RM, Freedman DM, Greenlee RT, et al.
Author(s): Benshushan A, Paltiel O, Rojansky N, Brzezinski A, Laufer N
Author(s): Parslov M, Lidegaard O, Klintorp S, Pedersen B, Jønsson L, et al.
Author(s): Kelsey JL, LiVolsi VA, Holford TR, Fischer DB, Mostow ED, et al.
Author(s): Elwood JM, Cole P, Rothman KJ, Kaplan SD
Author(s): Parazzini F, La Vecchia C, Moroni S, Chatenoud L, Ricci E