Author(s): Al-Jarrah M, Matalka I, Aseri HA, Mohtaseb A, Smirnova IV, et al.
Background: Endometrial cancer is one of the most common types of gynecologic cancers. The ability of exercise to reduce the risk of endometrial cancer in women with type 2 diabetes has been established, but no studies have examined this link in type 1 diabetes.A randomized, controlled animal study was designed using a standard rat model of type 1 diabetes. The goal of this study was to investigate the ability of exercise to prevent increased levels of endometrial cancer biomarkers, estrogen receptor (ERα) and p16, and endometrial hyperplasia associated with diabetes.
Methods: FORTY FEMALE RATS WERE RANDOMIZED INTO FOUR GROUPS: sedentary control, exercise control, sedentary or exercised diabetic. Diabetes was induced by alloxan injection. A 4-week treadmill training program was initiated with the development of diabetes. Endometrial tissues were evaluated for hyperplasia and ERα and p16 levels and subcellular localization using microscopy.
Results: Severe diabetes lead to hyperplasia in the endometrial tissue in 70% of sedentary diabetic rats. Exercise-trained diabetic rats and the non-diabetic rats displayed no hyperplasia. The expression of ERα increased significantly (p < 0.02) while the expression level of p16 decreased significantly (p < 0.04) in the diabetic sedentary group compared to the non-diabetic groups. Exercise training led to a reversal in the percentage of p16 and ERα positive cells in diabetic rats.
Conclusions: Severe diabetes leads to hyperplasia of the endometrial tissue and increased ERα levels and decreased p16 levels in rats, which can be prevented with aerobic exercise.
Keywords: Diabetes; Estrogen receptor alpha; P16; Endometrial hyperplasia; Endometrial cancer; Exercise.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/21629542
Author(s): Kurman RJ, Norris HJ
Author(s): Lacey JV Jr, Ioffe OB, Ronnett BM, Rush BB, Richesson DA, et al.
Author(s): Reed SD, Newton KM, Clinton WL, Epplein M, Garcia R, et al.
Author(s): Kurman RJ, Shih IeM
Author(s): Lacey JV Jr, Sherman ME, Rush BB, Ronnett BM, Ioffe OB, et al.
Author(s): Ferenczy A
Author(s): Stein CJ, Colditz GA
Author(s): Reed SD, Newton KM, Garcia RL, Allison KH, Voigt LF, et al.
Author(s): Ricci E, Moroni S, Parazzini F, Surace M, Benzi G, et al.
Author(s): Bobrowska K, Kamiński P, Cyganek A, Pietrzak B, Jabiry-Zieniewicz Z, et al.
Author(s): Heller DS, Mosquera C, Goldsmith LT, Cracchiolo B
Author(s): Gregoriou O, Konidaris S, Vrachnis N, Bakalianou K, Salakos N, et al.
Author(s): DerSimonian R, Kacker R
Author(s): Higgins JP, Thompson SG, Deeks JJ, Altman DG
Author(s): Higgins JP, Thompson SG
Author(s): Egger M, Davey Smith G, Schneider M, Minder C
Author(s): Epplein M, Reed SD, Voigt LF, Newton KM, Holt VL, et al.
Author(s): Cheung AP
Author(s): Viola AS, Gouveia D, Andrade L, Aldrighi JM, Viola CF, et al.
Author(s): Kreiger N, Marrett LD, Clarke EA, Hilditch S, Woolever CA
Author(s): Weir HK, Sloan M, Kreiger N
Author(s): Epplein M, Reed SD, Voigt LF, Newton KM, Holt VL, et al.
Author(s): Nagamani M, Urban RJ
Author(s): Guh DP, Zhang W, Bansback N, Amarsi Z, Birmingham CL, et al.
Author(s): Tankó LB, Christiansen C
Author(s): Midgette AS, Baron JA
Author(s): Cramer DW, Barbieri RL, Muto MG, Kelly A, Brucks JP, et al.
Author(s): Willett W, Stampfer MJ, Bain C, Lipnick R, Speizer FE, et al.
Author(s): Gandini S, Botteri E, Iodice S, Boniol M, Lowenfels AB, et al.
Author(s): Botteri E, Iodice S, Bagnardi V, Raimondi S, Lowenfels AB, et al.
Author(s): Thune I, Furberg AS
Author(s): Schonfeld SJ, Hartge P, Pfeiffer RM, Freedman DM, Greenlee RT, et al.
Author(s): Benshushan A, Paltiel O, Rojansky N, Brzezinski A, Laufer N
Author(s): Parslov M, Lidegaard O, Klintorp S, Pedersen B, Jønsson L, et al.
Author(s): Kelsey JL, LiVolsi VA, Holford TR, Fischer DB, Mostow ED, et al.
Author(s): Elwood JM, Cole P, Rothman KJ, Kaplan SD
Author(s): Parazzini F, La Vecchia C, Moroni S, Chatenoud L, Ricci E
