Author(s): Parazzini F, La Vecchia C, Moroni S, Chatenoud L, Ricci E
The association between a family history of endometrial, breast and ovarian cancer and the risk of endometrial cancer was analyzed on the basis of data from a case-control study conducted in northern Italy between 1983 and 1993. A total of 726 histologically confirmed endometrial-cancer patients (median age 61) admitted to a network of general and teaching hospitals in the Greater Milan area were interviewed. The controls were 2,123 women (median age 59), admitted for acute, non-neoplastic, non-hormone-related diseases to the same network of hospitals where the cases had been identified, with admission diagnoses unrelated to any of the known or suspected risk factors for endometrial cancer. Among cases, 37 (5.1%) reported a history of endometrial cancer in first-degree relatives. The corresponding figure among controls was 77 (3.6%). In comparison with women with no family history of endometrial cancer, the odds ratio (OR) of endometrial cancer was 1.5 (95% CI [confidence interval], 1.0-2.3) in women with a history of endometrial cancer in first-degree relatives. No relation emerged between endometrial cancer and a family history of breast or ovarian cancer. These results suggest that a family history of endometrial cancer increases the risk of contracting the same disease. However, the proportion of cases attributable to this factor was small: less than 1% of endometrial cancers in this population were attributable to familial (and hence potentially genetic) factors.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/7960212
Author(s): Kurman RJ, Norris HJ
Author(s): Lacey JV Jr, Ioffe OB, Ronnett BM, Rush BB, Richesson DA, et al.
Author(s): Reed SD, Newton KM, Clinton WL, Epplein M, Garcia R, et al.
Author(s): Kurman RJ, Shih IeM
Author(s): Lacey JV Jr, Sherman ME, Rush BB, Ronnett BM, Ioffe OB, et al.
Author(s): Ferenczy A
Author(s): Stein CJ, Colditz GA
Author(s): Reed SD, Newton KM, Garcia RL, Allison KH, Voigt LF, et al.
Author(s): Ricci E, Moroni S, Parazzini F, Surace M, Benzi G, et al.
Author(s): Bobrowska K, Kamiński P, Cyganek A, Pietrzak B, Jabiry-Zieniewicz Z, et al.
Author(s): Heller DS, Mosquera C, Goldsmith LT, Cracchiolo B
Author(s): Gregoriou O, Konidaris S, Vrachnis N, Bakalianou K, Salakos N, et al.
Author(s): DerSimonian R, Kacker R
Author(s): Higgins JP, Thompson SG, Deeks JJ, Altman DG
Author(s): Higgins JP, Thompson SG
Author(s): Egger M, Davey Smith G, Schneider M, Minder C
Author(s): Epplein M, Reed SD, Voigt LF, Newton KM, Holt VL, et al.
Author(s): Cheung AP
Author(s): Viola AS, Gouveia D, Andrade L, Aldrighi JM, Viola CF, et al.
Author(s): Kreiger N, Marrett LD, Clarke EA, Hilditch S, Woolever CA
Author(s): Weir HK, Sloan M, Kreiger N
Author(s): Epplein M, Reed SD, Voigt LF, Newton KM, Holt VL, et al.
Author(s): Nagamani M, Urban RJ
Author(s): Al-Jarrah M, Matalka I, Aseri HA, Mohtaseb A, Smirnova IV, et al.
Author(s): Guh DP, Zhang W, Bansback N, Amarsi Z, Birmingham CL, et al.
Author(s): Tankó LB, Christiansen C
Author(s): Midgette AS, Baron JA
Author(s): Cramer DW, Barbieri RL, Muto MG, Kelly A, Brucks JP, et al.
Author(s): Willett W, Stampfer MJ, Bain C, Lipnick R, Speizer FE, et al.
Author(s): Gandini S, Botteri E, Iodice S, Boniol M, Lowenfels AB, et al.
Author(s): Botteri E, Iodice S, Bagnardi V, Raimondi S, Lowenfels AB, et al.
Author(s): Thune I, Furberg AS
Author(s): Schonfeld SJ, Hartge P, Pfeiffer RM, Freedman DM, Greenlee RT, et al.
Author(s): Benshushan A, Paltiel O, Rojansky N, Brzezinski A, Laufer N
Author(s): Parslov M, Lidegaard O, Klintorp S, Pedersen B, Jønsson L, et al.
Author(s): Kelsey JL, LiVolsi VA, Holford TR, Fischer DB, Mostow ED, et al.
Author(s): Elwood JM, Cole P, Rothman KJ, Kaplan SD