Author(s): Guh DP, Zhang W, Bansback N, Amarsi Z, Birmingham CL, et al.
Background: Overweight and obese persons are at risk of a number of medical conditions which can lead to further morbidity and mortality. The primary objective of this study is to provide an estimate of the incidence of each co-morbidity related to obesity and overweight using a meta-analysis.
Methods: A literature search for the twenty co-morbidities identified in a preliminary search was conducted in Medline and Embase (Jan 2007). Studies meeting the inclusion criteria (prospective cohort studies of sufficient size reporting risk estimate based on the incidence of disease) were extracted. Study-specific unadjusted relative risks (RRs) on the log scale comparing overweight with normal and obese with normal were weighted by the inverse of their corresponding variances to obtain a pooled RR with 95% confidence intervals (CI).
Results: A total of 89 relevant studies were identified. The review found evidence for 18 co-morbidities which met the inclusion criteria. The meta-analysis determined statistically significant associations for overweight with the incidence of type II diabetes, all cancers except esophageal (female), pancreatic and prostate cancer, all cardiovascular diseases (except congestive heart failure), asthma, gallbladder disease, osteoarthritis and chronic back pain. We noted the strongest association between overweight defined by body mass index (BMI) and the incidence of type II diabetes in females (RR = 3.92 (95% CI: 3.10-4.97)). Statistically significant associations with obesity were found with the incidence of type II diabetes, all cancers except esophageal and prostate cancer, all cardiovascular diseases, asthma, gallbladder disease, osteoarthritis and chronic back pain. Obesity defined by BMI was also most strongly associated with the incidence of type II diabetes in females (12.41 (9.03-17.06)).
Conclusion: Both overweight and obesity are associated with the incidence of multiple co-morbidities including type II diabetes, cancer and cardiovascular diseases. Maintenance of a healthy weight could be important in the prevention of the large disease burden in the future. Further studies are needed to explore the biological mechanisms that link overweight and obesity with these co-morbidities.
Referred From: https://www.ncbi.nlm.nih.gov/pubmed/19320986
Author(s): Kurman RJ, Norris HJ
Author(s): Lacey JV Jr, Ioffe OB, Ronnett BM, Rush BB, Richesson DA, et al.
Author(s): Reed SD, Newton KM, Clinton WL, Epplein M, Garcia R, et al.
Author(s): Kurman RJ, Shih IeM
Author(s): Lacey JV Jr, Sherman ME, Rush BB, Ronnett BM, Ioffe OB, et al.
Author(s): Ferenczy A
Author(s): Stein CJ, Colditz GA
Author(s): Reed SD, Newton KM, Garcia RL, Allison KH, Voigt LF, et al.
Author(s): Ricci E, Moroni S, Parazzini F, Surace M, Benzi G, et al.
Author(s): Bobrowska K, Kamiński P, Cyganek A, Pietrzak B, Jabiry-Zieniewicz Z, et al.
Author(s): Heller DS, Mosquera C, Goldsmith LT, Cracchiolo B
Author(s): Gregoriou O, Konidaris S, Vrachnis N, Bakalianou K, Salakos N, et al.
Author(s): DerSimonian R, Kacker R
Author(s): Higgins JP, Thompson SG, Deeks JJ, Altman DG
Author(s): Higgins JP, Thompson SG
Author(s): Egger M, Davey Smith G, Schneider M, Minder C
Author(s): Epplein M, Reed SD, Voigt LF, Newton KM, Holt VL, et al.
Author(s): Cheung AP
Author(s): Viola AS, Gouveia D, Andrade L, Aldrighi JM, Viola CF, et al.
Author(s): Kreiger N, Marrett LD, Clarke EA, Hilditch S, Woolever CA
Author(s): Weir HK, Sloan M, Kreiger N
Author(s): Epplein M, Reed SD, Voigt LF, Newton KM, Holt VL, et al.
Author(s): Nagamani M, Urban RJ
Author(s): Al-Jarrah M, Matalka I, Aseri HA, Mohtaseb A, Smirnova IV, et al.
Author(s): Tankó LB, Christiansen C
Author(s): Midgette AS, Baron JA
Author(s): Cramer DW, Barbieri RL, Muto MG, Kelly A, Brucks JP, et al.
Author(s): Willett W, Stampfer MJ, Bain C, Lipnick R, Speizer FE, et al.
Author(s): Gandini S, Botteri E, Iodice S, Boniol M, Lowenfels AB, et al.
Author(s): Botteri E, Iodice S, Bagnardi V, Raimondi S, Lowenfels AB, et al.
Author(s): Thune I, Furberg AS
Author(s): Schonfeld SJ, Hartge P, Pfeiffer RM, Freedman DM, Greenlee RT, et al.
Author(s): Benshushan A, Paltiel O, Rojansky N, Brzezinski A, Laufer N
Author(s): Parslov M, Lidegaard O, Klintorp S, Pedersen B, Jønsson L, et al.
Author(s): Kelsey JL, LiVolsi VA, Holford TR, Fischer DB, Mostow ED, et al.
Author(s): Elwood JM, Cole P, Rothman KJ, Kaplan SD
Author(s): Parazzini F, La Vecchia C, Moroni S, Chatenoud L, Ricci E