Iodine determination in biological materials options for sample preparation and final determination

This paper describes the development of various new acid sample decomposition methods, as well as an extraction (leaching) method and compares them with the “Schöniger Combustion” technique. The methods have been developed as sample preparation techniques for iodine determination in biological materials, especially in solid samples. ICP-MS (inductively coupled plasma mass spectrometry) and a catalytic technique are employed and discussed for the final determination of iodine concentrations. Accuracy and reliability of the different analytical methods are shown in the examples of different CRMs (certified reference materials) available for iodine. The results of an interlaboratory comparison are specifically presented for the extraction (leaching) method.