Atypical bone metastasis and radiation changes in a colon cancer: a case report and a review of the literature

Author(s): Oh YK, Park HC, Kim YS

Abstract

We report a unique case of skeletal metastasis with prominent soft tissue extension from a colon cancer in a 44-year-old male patient. Four years after the diagnosis of colon cancer, plain radiographic examinations revealed a prominent soft tissue mass associated with cortical destruction of the right femur. Palliative radiotherapy of the right femur was performed. After completing radiotherapy, massive remineralization was seen in the soft tissue component. With the assistance of pre- and post-radiotherapy computerized tomography images, obtained in the process of planning the radiotherapy, we reached the conclusion that in our case the pre-radiotherapy finding was an extreme case of eccentric expansion of the bony cortex due to the outgrowth of bony metastasis. Retrospectively, the initial prominent soft tissue mass associated with the cortical destruction seems to have been a protruding bone metastasis, extending from the medial aspect of the right femur. This peculiar feature with remineralization after radiotherapy should help explain the phenomenon of atypical bony metastasis from a radiological perspective.

Similar Articles

Does colon cancer ever metastasize to bone first? a temporal analysis of colorectal cancer progression

Author(s): Roth ES, Fetzer DT, Barron BJ, Joseph UA, Gayed IW, et al.

Natural history of bone metastasis in colorectal cancer: final results of a large Italian bone metastases study

Author(s): Santini D, Tampellini M, Vincenzi B, Ibrahim T, Ortega C, et al.

Treatment and prognosis in colorectal cancer patients with bone metastasis

Author(s): Nozue M, Oshiro Y, Kurata M, Seino K, Koike N, et al.

Changing patterns of bone and brain metastases in patients with colorectal cancer

Author(s): Sundermeyer ML, Meropol NJ, Rogatko A, Wang H, Cohen SJ

Global cancer statistics

Author(s): Jemal A, Bray F, Center MM, Ferlay J, Ward E, et al.